Fuses and relays Mercedes-Benz S-Class (W221 / С216; 2005 - 2009)

In the fall of 2005, the fifth generation of the Mercedes-Benz S-Class was presented at the Frankfurt International Motor Show under the code designation W221. The new S-Class became a little wider, longer and higher than its predecessor W220, and also received three new powerful engines (power increase amounted to 26%). In this article we will understand in detail fuse box diagrams Mercedes W221 / C216 (5th Gen; S-Class: S350, S450, S500, S65 AMG, S63) 2005, 2006, 2007, 2008, 2009 years of manufacture.

Here you will find the locations and photos of the mounting blocks. Also, we will separately mark the fuses responsible for the cigarette lighter and the fuel pump.

In the luggage compartment

Access is from the passenger compartment. You have to fold down the armrest. Then remove the trim and the plastic cover..,

Photo - an example of the fuse box execution.

Diagram
No.	Relay assignment
M	Terminal 15
N	Terminal 15R
O	Power outlet Relay
P	Rear window heater relay
Q	Charge air cooler circulation pump relay
R	Cigarette lighter relay Mercedes-Benz w221 / C216
S	fuel pump relay
No.	Purpose of fuses	A
115	Rear window heater	50
116	Engine 275: Charge air cooler circulation pump	10
117	Rear cigarette lighter fuse	15
118	Engine: 272, 273, 642: Mercedes W221 / С216 fuel pump fuse	30
119	Central control panel in the front of the passenger compartment	7.5
120	Not	-
121	Audio tuner control unit	10
122	COMAND	7.5
123	Front right reversible seat belt tensioner	40
124	Front left reversible seat belt tensioner	40
125	Not	-
126	Overhead control panel	25
127	Multicontour seat pneumatic pump	30
	Pneumatic pump for dynamic seat adjustment
128	Engine 275: Fuel pump control module	25
129	Overhead control panel	25
130	C216: Electric parking brake control module	30
131	Antenna amplifier module above the rear window	7.5
133	Trailer recognition control module	15
134	Trunk 12V power outlet	15
135	Radar Sensor Control Module (SGR)	7.5
	Close-range front radar sensor module
	Near-field radar sensor module in the rear section
136	Not used	-
137		-
138		-
139	Refrigerated box in the rear seat backrest	15
140	12V power outlet	15
141	Reversing camera control module	5
142	PTS control module (Parktronic)	7.5
	Distronic Plus: Radar sensor control unit (SGR)
143	Rear seat control module	25
144		25
145	Trailer recognition control module	20
146		25
147	HDS control module (remote trunk lid closing)	30
148	UHl control module (universal cell phone interface)	7.5
149	Voice Control System (SBS) Control Module	5
150	TV Combo Tuner (Analog / Digital)	7.5
151	Electric parking brake control module	25
152	Antenna amplifier module above rear window	7.5

In the passenger compartment

Tere there are two units responsible for the protection of the vehicle's electrical circuits.

Main fuse box

Located on the driver's side at the end of the instrument panel on the left side.

Diagram
No.	A	Appointment
92	40	Front Left Seat Control Module
93	7.5	Passive safety system control module
		Passenger Weight System (WSS) Control Module (USA)
94	-	Empty
95	-	Empty
96	5	RDK control module (tire pressure monitoring system (Siemens))
97	7.5	W221: Audio-Video Controller Control Unit (multimedia entertainment system in the rear of the passenger compartment)
98	-	Empty
99	-	Empty
100	-	Empty
101	10	Left display in the rear of the passenger compartment
		Right display in the rear of the passenger compartment
102	40	Front Right Seat Control Module
103	7.5	ESP control module
104	40	Audio Tuner Control Module
105	-	Empty
106	10	Electronic toll collection (ETC) control unit (Japan)
107	5	C216: SDAR block
108	5	Rear air conditioner control module
109	15	W221: Intermediate plug connection for electric rear passenger compartment fan
110	7.5	W221: Rear left and right seat backrest control module
111	5	HBF control module
112	5	W221 front left and right door control module
113	-	Empty

Additional fuse box

Located on the passenger side at the end of the instrument panel on the right side.

The photo is an example of the driver's side fuse box.

Diagram
No.	A	Description
70	40	C216:  Door block, left
		W221:  Front door block right
71	15	Keyless-Go block
72	-	Not used
73	5	Control module COMAND (Japan)
74	30	HDS control unit (tailgate remote closing)
75-78	-	Not
79	7.5	Alarm siren with additional battery
80	40	C216:  Left door module
		W221:  Front left door unit
81	30	Fond control module
	40	Rear left door unit
82	30	Fond control module
	40	Rear left door unit
83	30	Automatic transmission servo module for DIRECT SELECT (A80)
84-89	-	Not
90	20	C216:  Heater STH (auxiliary heater)
		W221:  Heater STH or ZUH (auxiliary heater)
91	5	Receiving unit for radio remote control of the STH autonomous heater

In the engine compartment

Here there are two units responsible for the protection of the vehicle's electrical circuits.

Main fuse box

The main underhood fuse box is located at the top right.

Photo - general view.

Diagram
No.	Relay assignment
A	Air pump
B	Air suspension compressor
C	Terminal 87 relay, Engine
D	Terminal 15 relay
E	Relay circuit terminal 87, running gear
F	Horn (beep) relay
G	Terminal 15R
H	Relay circuit terminal 50, starter relay
J	Relay circuit terminal 15, starter relay
K	Preheating the wiper blades
No.	A	Purpose of fuses
20	10	Engine: 642: CDI system control unit
		Engine: 272, 273, 275: ME control unit
21	20	Motor: 272, 273, 275: Cable lug for electrical circuit terminal 87 M1i
22	15	Motor: 272, 273: Cable lug of electrical circuit terminal 87
23	20	Cable lug for electrical circuit terminal 87
		Engine: 275 (C216): Cable lug for electrical circuit terminal 87 M1i
		Engine: 273 (C216): Cable lug for electrical circuit terminal M2e
		Motor: 272, 273 (W221): Cable lug electrical circuit terminal 87M2i
		Engine: 642: Cable lug electr. terminal 87 circuit
24	25	Engine: 272, 273: Cable lug electr. circuit terminal 87M1e
		Engine: 642: CDI system control unit
25	7.5	Instrument cluster
26	10	Front left headlight unit
27	10	Front right headlamp unit
28	7.5	Engine: 275: EGS control unit
		Except for engine 275 (W221): Automatic transmission control unit (VGS)
29	5	Rear SAM control unit with fuse and relay module
30	7.5	Engine: 642: CDI system control unit
		Engine: 272, 273: ME control unit
		Engine: 275:
		ME unit
		Fuel pump fuse
31	-	Not
32	-	Not
33	-	Not
34	-	Not
35	5	Electric parking brake control module
36	10	Diagnostic connector
37	7.5	EZS unit
38	7.5	Central interface control unit
39	7.5	Instrument cluster
40	7.5	Upper control panel
41	30	Subordinate electric wiper motor
42	30	Wiper drive electric motor
43	15	Front cigarette lighter fuse Mercedes w221 / c216
44	-	Not used
45	-	Not used
46	15	ABC system module (active body level control system)
		AIRmatic system module with ADS system (W221, without ABC (Active Body Level Control))
47	15	SAM module with fuse and relay module, front
48	15
49	10	Steering column electronics
50	15	KLA module
51	7.5	COMAND display
52a	-	Not
52b	15	Horn (beep) left
		Horn (beep) right
53	30	AKP servo module for DIRECT SELECT
54	40	Cabin air conditioning air recirculation unit
55	60	Engine: 272, 273: Electric air pump
56	40	Compressor module AIRmatic (W221, without ABC (active body level control))
57	40	Heated wiper blade home position zone.
60	-	Not used
61	7.5 10	C216: Passive safety systems module
	10	W221: Passive safety systems module
62	5	Night vision system module
63	-	Not used
64	7.5	W221 from 1.9.2006: Magnetic coil of the NECK-PRO head restraint of the front passenger seat / NECK-PRO driver's seat head restraint magnetic coil
65	-	Not
66	7.5	DTR module (Distronic, Distronic Plus)

Power fusible links

The power unit is located near the battery.

Power block elements
No.	A	Decryption
F32f1	400	Starter
F32f2	150	Except Engine 642: Alternator
	200	Engine 642: Alternator
F32f3	150	-
F32f4	150	Engine and air conditioning suction fan with integrated regulator
F32f5	200	Engine 642: PTC Auxiliary Heater
F32f6	200	SAM with fuse and relay module, front
F32f7	40	ESP
F32f8	25
F32f9	20	SAM with fuse and relay module, front
F32f10	7.5	Onboard supply control unit